Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

Accumulating evidence indicates that RNA oxidation is involved in a wide variety of neurological diseases and may be associated with neuronal deterioration during the process of neurodegeneration. However, previous studies were done in postmortem tissues or cultured neurons. Here, we used transgenic...

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Bibliographic Details
Main Authors: Yueming Chang, Qiongman Kong, Xiu Shan, Guilian Tian, Hristelina Ilieva, Don W Cleveland, Jeffrey D Rothstein, David R Borchelt, Philip C Wong, Chien-Liang Glenn Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2481395?pdf=render