The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis

Abstract Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy. The complete understanding of the mechanisms by which thalidomide affects the embryo development has not yet been obtained. The phenotypic similarity makes TE a phenocopy o...

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Bibliographic Details
Main Authors: Julia do Amaral Gomes, Thayne Woycinck Kowalski, Lucas Rosa Fraga, Gabriel S. Macedo, Maria Teresa Vieira Sanseverino, Lavínia Schuler-Faccini, Fernanda Sales Luiz Vianna
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-47739-8