PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4<sup>+</sup> T Cells

PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4<sup>+</sup> T Cells

Growing tumors avoid recognition and destruction by the immune system. During continuous stimulation of tumor-infiltrating lymphocytes (TILs) by tumors, TILs become functionally exhausted; thus, they become unable to kill tumor cells and to produce certain cytokines and lose their ability to prolife...

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Bibliographic Details
Main Authors: Iga Jancewicz, Joanna Szarkowska, Ryszard Konopinski, Malgorzata Stachowiak, Monika Swiatek, Katarzyna Blachnio, Szymon Kubala, Paulina Oksinska, Pawel Cwiek, Natalia Rusetska, Agnieszka Tupalska, Natalia Zeber-Lubecka, Ewa Grabowska, Bianka Swiderska, Agata Malinowska, Michal Mikula, Beata Jagielska, Jan Walewski, Janusz A. Siedlecki, Tomasz J. Sarnowski, Sergiusz Markowicz, Elzbieta A. Sarnowska
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
CD4<sup>+</sup> effector T cells
T cell exhaustion
SWI/SNF complex
PD-1
PD-L1
PD-L1/PD-1 axis
Online Access:https://www.mdpi.com/2072-6694/13/16/4148

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https://www.mdpi.com/2072-6694/13/16/4148

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