The host-encoded Heme Regulated Inhibitor (HRI) facilitates virulence-associated activities of bacterial pathogens.

The host-encoded Heme Regulated Inhibitor (HRI) facilitates virulence-associated activities of bacterial pathogens.

Here we show that cells lacking the heme-regulated inhibitor (HRI) are highly resistant to infection by bacterial pathogens. By examining the infection process in wild-type and HRI null cells, we found that HRI is required for pathogens to execute their virulence-associated cellular activities. Spec...

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Bibliographic Details
Main Authors: Niraj Shrestha, Justin Boucher, Wael Bahnan, Emily S Clark, Roland Rosqvist, Kenneth A Fields, Wasif N Khan, Kurt Schesser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707855?pdf=render

Internet

http://europepmc.org/articles/PMC3707855?pdf=render

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