Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice

Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice

<p>Abstract</p> <p>Background</p> <p>Metallothionein-I and -II (MT-I/II) is produced by reactive astrocytes in the injured brain and has been shown to have neuroprotective effects. The neuroprotective effects of MT-I/II can be replicated <it>in vitro </it>wh...

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Bibliographic Details
Main Authors: Pankhurst Michael W, Bennett William, Kirkcaldie Matthew TK, West Adrian K, Chung Roger S
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Journal of Neuroinflammation
Subjects:
Metallothionein
cryolesion
brain injury
alternatively activated macrophages
Online Access:http://www.jneuroinflammation.com/content/8/1/172

Internet

http://www.jneuroinflammation.com/content/8/1/172

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