Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in <i>Staphylococcus epidermidis</i>

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in <i>Staphylococcus epidermidis</i>

Herein, 15 phenylpiperazine 3-benzyl-5,5-dimethylhydantoin derivatives (<b>1</b>–<b>15</b>) were screened for modulatory activity towards Msr(A) efflux pump present in <i>S. epidermidis</i> bacteria. Synthesis, crystallographic analysis, biological studies in vitr...

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Bibliographic Details
Main Authors: Karolina Witek, Gniewomir Latacz, Aneta Kaczor, Joanna Czekajewska, Ewa Żesławska, Anna Chudzik, Elżbieta Karczewska, Wojciech Nitek, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
<i>Staphylococcus epidermidis</i>
efflux pump
Msr(A)
phenylpiperazine 5,5-dimethylhydantoins
efflux pump inhibitors
EPIs
Online Access:https://www.mdpi.com/1420-3049/25/17/3788

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https://www.mdpi.com/1420-3049/25/17/3788

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