Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration

Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration

Both in mice and humans, low expression levels of vascular endothelial growth factor (VEGF) are linked to adult-onset motor neuron disease or amyotrophic lateral sclerosis (ALS). The mechanism through which reduced VEGF levels result in this phenotype is unknown. We therefore examined the direct eff...

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Bibliographic Details
Main Authors: Ludo Van Den Bosch, Erik Storkebaum, Vicky Vleminckx, Lieve Moons, Ludo Vanopdenbosch, Wendy Scheveneels, Peter Carmeliet, Wim Robberecht
Format: Article
Language:English
Published: Elsevier 2004-10-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
ALS
Motor neuron
Neurotrophic factor
Vascular endothelial growth factor
Hypoxia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001330

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http://www.sciencedirect.com/science/article/pii/S0969996104001330

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