Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes.

Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, all...

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Bibliographic Details
Main Authors: Kasper Winther Jørgensen, Søren Buus, Morten Nielsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012731?pdf=render