Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence.

Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certain co-morbidities. Novel anti-inflammatory drugs a...

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Bibliographic Details
Main Authors: Rory Blackler, Stephanie Syer, Manlio Bolla, Ennio Ongini, John L Wallace
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3322164?pdf=render