Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression

Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression

Abstract Background Mps1 binding protein (MOB1) is one of the core components of the mammalian Hippo pathway and plays important roles in cancer development. However, its expression, function and regulation in pancreatic ductal adenocarcinoma (PDAC) have not been revealed yet. Methods The expression...

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Bibliographic Details
Main Authors: Ming Quan, Zhiqin Chen, Feng Jiao, Xiuying Xiao, Qing Xia, Jingde Chen, Qian Chao, Yandong Li, Yong Gao, Haiyan Yang, Liwei Wang, Jiujie Cui
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic Cancer
MOB1
KDM2B
Hippo signaling
Online Access:https://doi.org/10.1186/s13046-019-1489-0

Internet

https://doi.org/10.1186/s13046-019-1489-0

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