Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Five point mutations within the amyloid β-protein (Aβ) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch) and the D23N (Iowa) amino acid substitutions....

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Bibliographic Details
Main Authors: Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid beta-protein
Aggregation
Degradation
Insulin degrading enzyme
Plasmin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001253

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http://www.sciencedirect.com/science/article/pii/S0969996108001253

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