The role of spatially controlled cell proliferation in limb bud morphogenesis.

Although the vertebrate limb bud has been studied for decades as a model system for spatial pattern formation and cell specification, the cellular basis of its distally oriented elongation has been a relatively neglected topic by comparison. The conventional view is that a gradient of isotropic prol...

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Bibliographic Details
Main Authors: Bernd Boehm, Henrik Westerberg, Gaja Lesnicar-Pucko, Sahdia Raja, Michael Rautschka, James Cotterell, Jim Swoger, James Sharpe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2903592?pdf=render