A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.

A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.

Hypothalamic neurosecretory systems are fundamental regulatory circuits influenced by thyroid hormone. Monocarboxylate-transporter-8 (MCT8)-mediated uptake of thyroid hormone followed by type 3 deiodinase (D3)-catalyzed inactivation represent limiting regulatory factors of neuronal T3 availability....

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Bibliographic Details
Main Authors: Imre Kalló, Petra Mohácsik, Barbara Vida, Anikó Zeöld, Zsuzsanna Bardóczi, Ann Marie Zavacki, Erzsébet Farkas, Andrea Kádár, Erik Hrabovszky, Rafael Arrojo E Drigo, Liping Dong, László Barna, Miklós Palkovits, Beáta A Borsay, László Herczeg, Ronald M Lechan, Antonio C Bianco, Zsolt Liposits, Csaba Fekete, Balázs Gereben
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3377717?pdf=render

Internet

http://europepmc.org/articles/PMC3377717?pdf=render

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