Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFA<i>lin</i>-Modified Peptidic Radioligands Targeting Both Integrin α<sub>v</sub>β<sub>3</sub> and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?
Combining two peptides addressing two different receptors to a heterobivalent peptidic ligand (HBPL) is thought to enable an improved tumor-targeting sensitivity and thus tumor visualization, compared to monovalent peptide ligands. In the case of melanoma, the Melanocortin-1 receptor (MC1R), which i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/6/547 |