Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement

Symmetric or asymmetric positioning of intracellular structures such as the nucleus and mitotic spindle steers various biological processes. Here authors use an in vitro model and show that a tug-of-war between centripetal actomyosin waves and percolation of bulk actomyosin network direct the positi...

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Bibliographic Details
Main Authors: Ryota Sakamoto, Masatoshi Tanabe, Tetsuya Hiraiwa, Kazuya Suzuki, Shin’ichi Ishiwata, Yusuke T. Maeda, Makito Miyazaki
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16677-9