Xiaochaihutang Improves the Cortical Astrocyte Edema in Thioacetamide-Induced Rat Acute Hepatic Encephalopathy by Activating NRF2 Pathway

Xiaochaihutang Improves the Cortical Astrocyte Edema in Thioacetamide-Induced Rat Acute Hepatic Encephalopathy by Activating NRF2 Pathway

Oxidative stress induced by high ammonia, which leads to astrocyte edema, is the key to acute hepatic encephalopathy (AHE). Nuclear factor erythroid 2-related factor 2 (NRF2) has been implicated in oxidative stress, but the mechanism of NRF2 against ammonia-induced astrocytes edema has not been full...

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Bibliographic Details
Main Authors: Weiyi Jia, Jiajia Liu, Rui Hu, Anling Hu, Weiwei Tang, Lijuan Li, Jin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
Xiaochaihutang
acute hepatic encephalopathy
NRF2 pathway
brain edema
astrocyte edema
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00382/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00382/full

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