Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation

Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation

Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. Integrins are involved in FGF signaling, since integrin antagonists suppress FGF signaling. This is called integrin-FGF crosstalk, while the specifics of the crosstalk are uncle...

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Bibliographic Details
Main Authors: Seiji Mori, Yoshikazu Takada
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Medical Sciences
Subjects:
FGF1
integrin
crosstalk
dominant-negative mutant
Online Access:http://www.mdpi.com/2076-3271/1/1/20

Internet

http://www.mdpi.com/2076-3271/1/1/20

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