Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function

Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function

Myopathies are notably associated with mutations in genes encoding proteins known to be essential for the force production of skeletal muscle fibers, such as skeletal alpha-actin. The exact molecular mechanisms by which these specific defects induce myopathic phenotypes remain unclear. Hence, in the...

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Bibliographic Details
Main Authors: Jun Fan, Chun Chan, Elyshia L. McNamara, Kristen J. Nowak, Hiroyuki Iwamoto, Julien Ochala
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
actin mutation
myopathy
muscle force
actin mechanics
muscle fiber
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01756/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01756/full

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