VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiology

Mutations in VPS35 (PARK17), a key molecule in the retromer complex, are a rare cause of autosomal dominant Parkinson's disease (PD), the second most common neurodegenerative disorder. VPS35 exerts crucial functions within the cell in terms of regulating endosomal trafficking. However new data...

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Bibliographic Details
Main Authors: Gianni Cutillo, David K. Simon, Simona Eleuteri
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303314