DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

Abstract Background Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms have not been fully elucidated. Our recent work demonstrates that DR5 supp...

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Bibliographic Details
Main Authors: You-Take Oh, Ping Yue, Shi-Yong Sun
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cell Communication and Signaling
Subjects:
Death receptor 5
Invasion
S1P
Caspase-8
TRAF2
Polyubiquitination
Online Access:http://link.springer.com/article/10.1186/s12964-017-0174-1

Internet

http://link.springer.com/article/10.1186/s12964-017-0174-1

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