Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension

Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension

Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor (BMPR2) mutations seen in pulmonary arterial hypertension (PAH). However, standard 2D cell culture models fail to mimic the mechanical environment seen in the pulmonary vasculature. Hydrogels have emerged a...

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Bibliographic Details
Main Authors: Reid W. D’Amico, Shannon Faley, Ha-na Shim, Joanna R. Prosser, Vineet Agrawal, Leon M. Bellan, James D. West
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary arterial hypertension
endothelial dysfunction
disease modeling
Online Access:http://www.mdpi.com/1422-0067/19/9/2561

Internet

http://www.mdpi.com/1422-0067/19/9/2561

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