Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate syn...

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Bibliographic Details
Main Authors: Bárbara Velame Ferreira Teixeira, André Lacerda Braga Teles, Suellen Gonçalves da Silva, Camila Carane Bitencourt Brito, Humberto Fonseca de Freitas, Acássia Benjamim Leal Pires, Thamires Quadros Froes, Marcelo Santos Castilho
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
dual inhibitors
pteridine reductase 1
dihydrofolate reductase-thymidylate synthase
leishmania chagasi
selective inhibitors
Online Access:http://dx.doi.org/10.1080/14756366.2019.1651311

Internet

http://dx.doi.org/10.1080/14756366.2019.1651311

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