Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

Synovial sarcoma (SS) is frequently diagnosed in teenagers and young adults and continues to be treated with polychemotherapy with variable success. The SS18-SSX gene fusion is pathognomonic for the disease, and high expression of the anti-apoptotic BCL-2 pathologically supports the diagnosis. As th...

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Bibliographic Details
Main Authors: Carter K. Fairchild, Konstantinos V. Floros, Sheeba Jacob, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Hisashi Harada, Mikhail G. Dozmorov, Jennifer E. Koblinski, Steven C. Smith, Gregory Domson, Joel D. Leverson, Andrew J. Souers, Naoko Takebe, Hiromichi Ebi, Anthony C. Faber, Sosipatros A. Boikos
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
synovial sarcoma
BCL-2
apoptosis
Online Access:https://www.mdpi.com/2072-6694/13/10/2310

Internet

https://www.mdpi.com/2072-6694/13/10/2310

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