SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks

SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks

Rhabdomyosarcoma (RMS) is a predominant soft tissue tumor in children and adolescents. For high-grade RMS with metastatic involvement, the 3-year overall survival rate is only 25 to 30%. Thus, understanding the regulatory mechanisms involved in promoting the metastasis of RMS is important. Here, we...

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Bibliographic Details
Main Authors: Klaudia Skrzypek, Marta Kot, Paweł Konieczny, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota, Wojciech Bobela, Urszula Jankowska, Sylwia Kędracka-Krok, Marcin Majka
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
rhabdomyosarcoma (RMS)
tumor metastasis
SNAIL transcription factor
microRNA (miRNA)
EZRIN
AKT kinase
Online Access:https://www.mdpi.com/2072-6694/12/7/1870

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https://www.mdpi.com/2072-6694/12/7/1870

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