CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway

CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway

Abstract Background The NSD family of histone lysine methyltransferases have emerged as important biomarkers that participate in a variety of malignancies. Recent evidence has indicated that somatic dysregulation of the nuclear receptor binding SET domain-containing protein 1 (NSD1) is associated wi...

Full description

Bibliographic Details
Main Authors: Shuhua Zhang, Fan Zhang, Qing Chen, Chidan Wan, Jun Xiong, Jianqun Xu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
NSD1
Wnt10b
Wnt/β-catenin signaling pathway
CRISPR/Cas9
Human hepatocellular carcinoma
Proliferation
Online Access:http://link.springer.com/article/10.1186/s13046-019-1462-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1462-y

Similar Items