A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.

A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.

Activation-induced cytidine deaminase (AID) is believed to initiate somatic hypermutation (SHM) by deamination of deoxycytidines to deoxyuridines within the immunoglobulin variable regions genes. The deaminated bases can subsequently be replicated over, processed by base excision repair or mismatch...

Full description

Bibliographic Details
Main Authors: Likun Du, Deborah K Dunn-Walters, Krystyna H Chrzanowska, Tanja Stankovic, Ashwin Kotnis, Xin Li, Jiayi Lu, Gösta Eggertsen, Claire Brittain, Sergey W Popov, Andrew R Gennery, A Malcolm R Taylor, Qiang Pan-Hammarström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2423615?pdf=render

Internet

http://europepmc.org/articles/PMC2423615?pdf=render

Similar Items