Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

Abstract Background Mismatch Repair Deficiency (MMR-D)-related tumors are highly immunogenic and constitute ideal vaccination targets. In a proof-of-concept study delayed tumorigenesis and prolonged survival has been shown in a clinically-relevant mouse model for MMR-D-related diseases (=MLH1 knock...

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Bibliographic Details
Main Authors: Claudia Maletzki, Leonie Wiegele, Ingy Nassar, Jan Stenzel, Christian Junghanss
Format: Article
Language:English
Published: BMJ Publishing Group 2019-01-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Tumor lysate
Gemcitabine
MMR deficiency
In vivo imaging
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s40425-018-0476-x

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http://link.springer.com/article/10.1186/s40425-018-0476-x

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