Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

Abstract Background The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related...

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Bibliographic Details
Main Authors: Qing Zhang, Agnès Duplany, Vincent Moncollin, Sandrine Mouradian, Evelyne Goillot, Laetitia Mazelin, Karine Gauthier, Nathalie Streichenberger, Céline Angleraux, Jie Chen, Shuzhe Ding, Laurent Schaeffer, Yann‐Gaël Gangloff
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
mTOR kinase activity
Myopathy
Mitochondria
Glycogen
Body composition
Online Access:https://doi.org/10.1002/jcsm.12336

Internet

https://doi.org/10.1002/jcsm.12336

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