EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model.

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model.

EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with half-maximal effective concentrations (EC50s) of 21, 23 and 64 nM agai...

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Bibliographic Details
Main Authors: Michael H J Rhodin, Nicole V McAllister, Jonathan Castillo, Sarah L Noton, Rachel Fearns, In Jong Kim, Jianming Yu, Thomas P Blaisdell, Joseph Panarese, Brian C Shook, Yat Sun Or, Bryan Goodwin, Kai Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009428

Internet

https://doi.org/10.1371/journal.ppat.1009428

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