Mechanisms of antibacterial action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae

Mechanisms of antibacterial action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae

Quinoxaline 1,4-di-N-oxides (QdNOs) are a class of bioreductive compounds, however their antibacterial mechanisms are still unclarified. The aim of this study was to assess the ability of two representative QdNO drugs, cyadox (CYA) and olaquindox (OLA), to produce reactive oxide species (ROS) in Gra...

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Bibliographic Details
Main Authors: Fanfan Xu, Guyue Cheng, Yulian Wang, Haihong Hao, Xu Wang, Dongmei Chen, Dapeng Peng, Zhenli Liu, Menghong Dai, Zonghui Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Microbiology
Subjects:
Brachyspira hyodysenteriae
Cell Membrane
Cell Wall
Clostridium perfringens
DNA Damage
Quinoxaline 1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01948/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01948/full

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