Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (ΔE) TorsinA in transgenic mice

Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (ΔE) TorsinA in transgenic mice

Early onset torsion dystonia is an autosomal dominant movement disorder of variable penetrance caused by a glutamic acid, i.e. ΔE, deletion in DYT1, encoding the protein TorsinA. Genetic and structural data implicate basal ganglia dysfunction in dystonia. TorsinA, however, is diffusely expressed, an...

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Bibliographic Details
Main Authors: Michelle E. Page, Li Bao, Pierrette Andre, Joshua Pelta-Heller, Emily Sluzas, Pedro Gonzalez-Alegre, Alexey Bogush, Loren E. Khan, Lorraine Iacovitti, Margaret E. Rice, Michelle E. Ehrlich
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Dystonia
Tyrosine hydroxylase
Dopamine
DYT1
TorsinA
Striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001324

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110001324

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