New orally active artemisinin dimer antimalarials
Objective: To synthesize orally bioavailable artemisinin dimers and the evaluation of their in vivo antimalarial activity. Methods: Artemsisin dimers were synthesized and their antimalarial activity was determined in in vitro and in vivo studies (administered orally and IP). Results: Dimers 5 and 6...
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Wolters Kluwer Medknow Publications
2017-01-01
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doaj-48170b2c66cc41108af91e7d87606a1d2020-11-25T02:09:16ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712589-28942017-01-013311110.4103/wjtcm.wjtcm_10_17New orally active artemisinin dimer antimalarialsMahmoud A ElSohlyWaseem GulShabana I KhanBabu L TekwaniObjective: To synthesize orally bioavailable artemisinin dimers and the evaluation of their in vivo antimalarial activity. Methods: Artemsisin dimers were synthesized and their antimalarial activity was determined in in vitro and in vivo studies (administered orally and IP). Results: Dimers 5 and 6 provided 100% suppression of parastemia throughout the oral administration study, with all animals surviving up to day 28 (the last day of the study). Conclusion: Dimers 4-7 displayed markedly improved in vitro activity against P. falciparum, while the in vivo activity against P. berghei was highly encouraging, with 5 and 6 completely clearing parasitemia from the start of the drug treatment until the end of the study (day 28).http://www.wjtcm.net/article.asp?issn=2311-8571;year=2017;volume=3;issue=3;spage=1;epage=11;aulast=ElSohlyArtemisininArtemisinin dimerPlasmodium bergheiPlasmodium falciparum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahmoud A ElSohly Waseem Gul Shabana I Khan Babu L Tekwani |
spellingShingle |
Mahmoud A ElSohly Waseem Gul Shabana I Khan Babu L Tekwani New orally active artemisinin dimer antimalarials World Journal of Traditional Chinese Medicine Artemisinin Artemisinin dimer Plasmodium berghei Plasmodium falciparum |
author_facet |
Mahmoud A ElSohly Waseem Gul Shabana I Khan Babu L Tekwani |
author_sort |
Mahmoud A ElSohly |
title |
New orally active artemisinin dimer antimalarials |
title_short |
New orally active artemisinin dimer antimalarials |
title_full |
New orally active artemisinin dimer antimalarials |
title_fullStr |
New orally active artemisinin dimer antimalarials |
title_full_unstemmed |
New orally active artemisinin dimer antimalarials |
title_sort |
new orally active artemisinin dimer antimalarials |
publisher |
Wolters Kluwer Medknow Publications |
series |
World Journal of Traditional Chinese Medicine |
issn |
2311-8571 2589-2894 |
publishDate |
2017-01-01 |
description |
Objective: To synthesize orally bioavailable artemisinin dimers and the evaluation of their in vivo antimalarial activity. Methods: Artemsisin dimers were synthesized and their antimalarial activity was determined in in vitro and in vivo studies (administered orally and IP). Results: Dimers 5 and 6 provided 100% suppression of parastemia throughout the oral administration study, with all animals surviving up to day 28 (the last day of the study). Conclusion: Dimers 4-7 displayed markedly improved in vitro activity against P. falciparum, while the in vivo activity against P. berghei was highly encouraging, with 5 and 6 completely clearing parasitemia from the start of the drug treatment until the end of the study (day 28). |
topic |
Artemisinin Artemisinin dimer Plasmodium berghei Plasmodium falciparum |
url |
http://www.wjtcm.net/article.asp?issn=2311-8571;year=2017;volume=3;issue=3;spage=1;epage=11;aulast=ElSohly |
work_keys_str_mv |
AT mahmoudaelsohly neworallyactiveartemisinindimerantimalarials AT waseemgul neworallyactiveartemisinindimerantimalarials AT shabanaikhan neworallyactiveartemisinindimerantimalarials AT babultekwani neworallyactiveartemisinindimerantimalarials |
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