Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

Abstract Background The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an ant...

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Bibliographic Details
Main Authors: Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangangari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Jason A. Konner, Thomas Reiner
Format: Article
Language:English
Published: SpringerOpen 2018-08-01
Series:EJNMMI Research
Subjects:
89Zr
Companion diagnostic
PET imaging
Antibody-drug-conjugate
Online Access:http://link.springer.com/article/10.1186/s13550-018-0437-x

Internet

http://link.springer.com/article/10.1186/s13550-018-0437-x

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