MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

Skeletal muscles are composed of hundreds of multinucleated muscle fibers (myofibers) whose myonuclei are regularly positioned all along the myofiber’s periphery except the few ones clustered underneath the neuromuscular junction (NMJ) at the synaptic zone. This precise myonuclei organization is alt...

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Bibliographic Details
Main Authors: Alireza Ghasemizadeh, Emilie Christin, Alexandre Guiraud, Nathalie Couturier, Marie Abitbol, Valerie Risson, Emmanuelle Girard, Christophe Jagla, Cedric Soler, Lilia Laddada, Colline Sanchez, Francisco-Ignacio Jaque-Fernandez, Vincent Jacquemond, Jean-Luc Thomas, Marine Lanfranchi, Julien Courchet, Julien Gondin, Laurent Schaeffer, Vincent Gache
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
microtubules
nucleus
muscle fiber
mitochondria
neuromuscular junction
cytoskeleton
Online Access:https://elifesciences.org/articles/70490

Internet

https://elifesciences.org/articles/70490

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