Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution.

Insulin-Degrading-Enzyme (IDE) is a Zn2+-dependent peptidase highly conserved throughout evolution and ubiquitously distributed in mammalian tissues wherein it displays a prevalent cytosolic localization. We have recently demonstrated a novel Heat Shock Protein-like behaviour of IDE and its associat...

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Bibliographic Details
Main Authors: Diego Sbardella, Grazia Raffaella Tundo, Francesca Sciandra, Manuela Bozzi, Magda Gioia, Chiara Ciaccio, Umberto Tarantino, Andrea Brancaccio, Massimo Coletta, Stefano Marini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0132455