Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates.

Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates.

Strong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDNF) to the regulation of energy homeostasis, with loss-of-function mutations in either gene causing severe obesity in both mice and humans. It has previously been repor...

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Bibliographic Details
Main Authors: Mylène Perreault, Guo Feng, Sarah Will, Tiffany Gareski, David Kubasiak, Kimberly Marquette, Yulia Vugmeyster, Thaddeus J Unger, Juli Jones, Ariful Qadri, Seung Hahm, Ying Sun, Cynthia M Rohde, Raphael Zwijnenberg, Janet Paulsen, Ruth E Gimeno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3659094?pdf=render

Internet

http://europepmc.org/articles/PMC3659094?pdf=render

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