TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

Systemic delivery of recombinant Bcl-xL fusion protein containing the TAT protein transduction domain attenuated neonatal brain damage following hypoxic ischemia (H–I). Within 30 min after intraperitoneal injection of TAT–Bcl-xL protein into 7-day-old rats, substantially enhanced levels of Bcl-xL we...

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Bibliographic Details
Main Authors: Wei Yin, Guodong Cao, Michael J. Johnnides, Armando P. Signore, Yumin Luo, Robert W. Hickey, Jun Chen
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Subjects:
Protein transduction
Hypoxia
Ischemia
Apoptosis
Cerebral
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002147

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http://www.sciencedirect.com/science/article/pii/S0969996105002147

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