Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach

Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach

The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeostasis. XIAP is overexpressed in tumours, potentiatin...

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Bibliographic Details
Main Authors: Panagis Polykretis, Enrico Luchinat, Alessio Bonucci, Andrea Giachetti, Melissa A. Graewert, Dmitri I. Svergun, Lucia Banci
Format: Article
Language:English
Published: International Union of Crystallography 2019-09-01
Series:IUCrJ
Subjects:
X-chromosome-linked inhibitor of apoptosis protein
full-length XIAP
SAXS
EPR
integrative structural biology
Online Access:http://scripts.iucr.org/cgi-bin/paper?S205225251901073X

Internet

http://scripts.iucr.org/cgi-bin/paper?S205225251901073X

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