Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils

Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils

Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T cells, but was independent of IFN-γ and other classi...

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Bibliographic Details
Main Authors: Beate J. Müller, Arne Westheider, Katharina Birkner, Birte Seelig, Susanne Kirschnek, Christian Bogdan, Friederike D. von Loewenich
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Anaplasma phagocytophilum
TLR
NLR
CLR
MyD88
iNOS
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.627630/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.627630/full

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