Structural basis for the assembly of the Ragulator-Rag GTPase complex
mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains.
Bibliographic Details
| Main Authors: |
Ryo Yonehara,
Shigeyuki Nada,
Tomokazu Nakai,
Masahiro Nakai,
Ayaka Kitamura,
Akira Ogawa,
Hirokazu Nakatsumi,
Keiichi I. Nakayama,
Songling Li,
Daron M. Standley,
Eiki Yamashita,
Atsushi Nakagawa,
Masato Okada |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01762-3
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