Effects of sulforaphane and its S- and R-enantiomers on the expression and activities of human drug-metabolizing cytochromes P450

Effects of sulforaphane and its S- and R-enantiomers on the expression and activities of human drug-metabolizing cytochromes P450

The effects of S/R-enantiomers of sulforaphane on drug-metabolizing cytochromes P450, in particular: (i) expression of CYP1A1/2, CYP2B6, CYP2C9, CYP3A4 mRNAs and proteins in human hepatocytes; (ii) mRNA expression and activity of pregnane X receptor (PXR), aryl hydrocarbon receptor (AhR) and glucoco...

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Bibliographic Details
Main Authors: Alzbeta Srovnalova, Alena Vanduchova, Michaela Svecarova, Eva Anzenbacherova, Veronika Tomankova, Pavel Anzenbacher, Zdenek Dvorak
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Functional Foods
Subjects:
Sulforaphane
Enantiomer
Xenoreceptors
Cytochrome P450
Human hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615000687

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http://www.sciencedirect.com/science/article/pii/S1756464615000687

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