Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation

Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation

Abstract Hematopoietic disorders, particularly hemolytic anemias, commonly lead to bone loss. We have previously reported that actively proliferating cancer cells stimulate osteoclastogenesis from late precursors in a RANKL‐independent manner. We theorized that cancer cells exploit the physiological...

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Bibliographic Details
Main Authors: Gulzhakhan Sadvakassova, Kerstin Tiedemann, Kieran J. D. Steer, Nicholas Mikolajewicz, Mariya Stavnichuk, Irene In‐Kyung Lee, Zarina Sabirova, Matthias Schranzhofer, Svetlana V. Komarova
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Physiological Reports
Subjects:
anemia
bone
hematopoiesis
osteoclasts
PRDX2
Online Access:https://doi.org/10.14814/phy2.14745

Internet

https://doi.org/10.14814/phy2.14745

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