Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation
Abstract Hematopoietic disorders, particularly hemolytic anemias, commonly lead to bone loss. We have previously reported that actively proliferating cancer cells stimulate osteoclastogenesis from late precursors in a RANKL‐independent manner. We theorized that cancer cells exploit the physiological...
Main Authors: | Gulzhakhan Sadvakassova, Kerstin Tiedemann, Kieran J. D. Steer, Nicholas Mikolajewicz, Mariya Stavnichuk, Irene In‐Kyung Lee, Zarina Sabirova, Matthias Schranzhofer, Svetlana V. Komarova |
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Format: | Article |
Language: | English |
Published: |
Wiley
2021-02-01
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Series: | Physiological Reports |
Subjects: | |
Online Access: | https://doi.org/10.14814/phy2.14745 |
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