CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression

CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression

Abstract Background Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulators have not been investigated. Methods The phosphorylation status was i...

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Bibliographic Details
Main Authors: Yichong Ning, Chunqing Wang, Xin Liu, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zhou, Chang Zhou
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Protein kinase CK2
CCDC106
p53
Breast cancer
Cervical cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1137-8

Internet

http://link.springer.com/article/10.1186/s13046-019-1137-8

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