The latency-associated transcript locus of herpes simplex virus 1 is a virulence determinant in human skin.

The latency-associated transcript locus of herpes simplex virus 1 is a virulence determinant in human skin.

Herpes simplex virus 1 (HSV-1) infects skin and mucosal epithelial cells and then travels along axons to establish latency in the neurones of sensory ganglia. Although viral gene expression is restricted during latency, the latency-associated transcript (LAT) locus encodes many RNAs, including a 2 k...

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Bibliographic Details
Main Authors: Emilia A H Vanni, Joseph W Foley, Andrew J Davison, Marvin Sommer, Dongmei Liu, Phillip Sung, Jennifer Moffat, Leigh Zerboni, Ann M Arvin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009166

Internet

https://doi.org/10.1371/journal.ppat.1009166

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