MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

Methyl-CpG-binding-Protein 2 (MeCP2) is an abundant nuclear protein highly enriched in neurons. Here we report live-cell single-molecule imaging studies of the kinetic features of mouse MeCP2 at high spatial-temporal resolution. MeCP2 displays dynamic features that are distinct from both highly mobi...

Full description

Bibliographic Details
Main Authors: Francesco M Piccolo, Zhe Liu, Peng Dong, Ching-Lung Hsu, Elitsa I Stoyanova, Anjana Rao, Robert Tjian, Nathaniel Heintz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
single molecule tracking
MeCP2
nuclear diffusion
live imaging of neurons
Online Access:https://elifesciences.org/articles/51449

Internet

https://elifesciences.org/articles/51449

Similar Items