A Novel Prostate Cell Type-Specific Gene Signature to Interrogate Prostate Tumor Differentiation Status and Monitor Therapeutic Response (Running Title: Phenotypic Classification of Prostate Tumors)

A Novel Prostate Cell Type-Specific Gene Signature to Interrogate Prostate Tumor Differentiation Status and Monitor Therapeutic Response (Running Title: Phenotypic Classification of Prostate Tumors)

In this study, we extracted prostate cell-specific gene sets (metagenes) to define the epithelial differentiation status of prostate cancers and, using a deconvolution-based strategy, interrogated thousands of primary and metastatic tumors in public gene profiling datasets. We identified a subgroup...

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Bibliographic Details
Main Authors: Sarah N. Mapelli, Domenico Albino, Maurizia Mello-Grand, Dheeraj Shinde, Manuel Scimeca, Rita Bonfiglio, Elena Bonanno, Giovanna Chiorino, Ramon Garcia-Escudero, Carlo V. Catapano, Giuseppina M. Carbone
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
prostate cancer
tumor classification
predictive biomarkers
gene signature
gene classifier
Online Access:https://www.mdpi.com/2072-6694/12/1/176

Internet

https://www.mdpi.com/2072-6694/12/1/176

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