Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

While topotecan (TPT) is a first- and second-line chemotherapeutic drug in treating lung cancer, the development of drug resistance in tumors still reserves as a major obstacle to chemotherapeutic success. Therefore, a better understanding of the mechanisms of topotecan resistance is critical. In th...

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Bibliographic Details
Main Authors: Zi-Ning Lei, Qiu-Xu Teng, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Kimberly W. Lu, Dong-Hua Yang, John N. D. Wurpel, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
topotecan
non-small cell lung cancer
NCI-H460/TPT10
multidrug resistance
ABCG2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.607275/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.607275/full

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