Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with ginton...

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Bibliographic Details
Main Authors: Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung-Chun Kim, Mun Han, Eun-Hee Lee, Juyoung Park, Seung-Yeol Nah
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Ginseng Research
Subjects:
Alzheimer disease
Brain delivery
Donepezil
Ginseng
Gintonin
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845319302714

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http://www.sciencedirect.com/science/article/pii/S1226845319302714

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