Single Cell Transcriptome Analysis of Niemann–Pick Disease, Type C1 Cerebella

Single Cell Transcriptome Analysis of Niemann–Pick Disease, Type C1 Cerebella

Niemann–Pick disease, type C1 (NPC1) is a lysosomal disease characterized by endolysosomal storage of unesterified cholesterol and decreased cellular cholesterol bioavailability. A cardinal symptom of NPC1 is cerebellar ataxia due to Purkinje neuron loss. To gain an understanding of the cerebellar n...

Full description

Bibliographic Details
Main Authors: Antony Cougnoux, Julia C. Yerger, Mason Fellmeth, Jenny Serra-Vinardell, Kyle Martin, Fatemeh Navid, James Iben, Christopher A. Wassif, Niamh X. Cawley, Forbes D. Porter
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick disease
type C1
NPC1
single cell RNA sequencing
transcriptome
cerebellum
Online Access:https://www.mdpi.com/1422-0067/21/15/5368

Internet

https://www.mdpi.com/1422-0067/21/15/5368

Similar Items